Comparing Placental Histology of Vaccinated and Unvaccinated Pregnant Women During Active Coronavirus Disease 2019 Infection

Objective: We aim to compare the placental histology of vaccinated and unvaccinated women who delivered during active coronavirus disease 2019 infection.

Methods: Forty-two patients were enrolled to study, regardless of coronavirus disease 2019 severity, and they were divided into 2 groups according to their coronavirus disease 2019 vaccination status. Twenty-three patients who were vaccinated in the last 3-6 weeks were classified as a vaccinated group, and 19 patients who had not taken any coronavirus disease 2019 vaccination were classified as an unvaccinated group.

Results: The rate of existence of maternal vascular malperfusion features was significantly higher in the unvaccinated group compared to that of the vaccinated group. Decidual arteriopathy, accelerated villous maturation, increased syncytial knotting, perivillous fibrin plaque, and massive perivillous fibrin deposition were analyzed as maternal vascular malperfusion features. The most common maternal vascular malperfusion feature was decidual arteriopathy in both groups (73.6% in unvaccinated group and 22.7% vaccinated group). In the unvaccinated group, the rate of the existence of at least one of maternal vascular malperfusion features was 100%.

Conclusion: The higher rate of features of maternal vascular malperfusion of placental bed was detected in the placentas of unvaccinated pregnant women with coronavirus disease 2019 infection compared to that in the placentas of vaccinated pregnant women with acute coronavirus disease 2019 infection regardless of disease severity.

Cite this article as: Güven CM, & Avul, Z. (2023). Comparing placental histology of vaccinated and unvaccinated pregnant women during active coronavirus disease 2019 infection. Arch Basic Clin Res., 2023;5(3):344-349.