Archives of Basic and Clinical Research
Original Article

Platelet Activity Increases in Patients with Diabetic Retinopathy

1.

Department of Medical Biochemistry, Erzincan Binali Yıldırım University, Faculty of Medicine, Erzincan, Turkey

2.

Department of Medical Biochemistry, İnonu University Faculty of Medicine, Malatya, Turkey

3.

Department of Neurology, Erzincan Binali Yıldırım University, Faculty of Medicine, Erzincan, Turkey

4.

Department of Ophthalmology, Erzincan Binali Yıldırım University, Faculty of Medicine, Erzincan, Turkey

5.

Department of Internal Medicine, Erzincan Binali Yıldırım University, Faculty of Medicine, Erzincan, Turkey

Arch Basic Clin Res 2022; 4: 68-73
DOI: 10.5152/ABCR.2022.21020
Read: 179 Downloads: 125 Published: 08 July 2022

Objective: The role of new inflammatory markers such as neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, mean platelet volume, and platelet distribution width in diabetic microvascular complications was investigated.

Methods: A total of 266 (172 female, 94 male) individuals were divided into 5 groups: group 1, who have diabetes without any complications for at least 10 years; group 2, only diabetic nephropathy; group 3, only diabetic neuropathy; group 4, only diabetic retinopathy; and group 5, control group.

Results: Glucose and HbA1c were higher in retinopathy, neuropathy, and nephropathy groups than in the control group (P < .001). Neutrophil-lymphocyte ratio in the neuropathy group was higher in the retinopathy and uncomplicated diabetic groups (mean ± SD; 2.4 ± 2.9, 1.6 ± 0.5, 1.5 ± 0.5, P = .018, P = .001, respectively), and platelet-lymphocyte ratio was higher only in the retinopathy group (mean ± SD; 133.8 ± 59, 105.5 ± 34, P = .001). In the retinopathy group, mean platelet volume and platelet distribution width were higher than the control group and the uncomplicated diabetic group (mean platelet volume mean ± SD; 10.6 ± 1.0, 10.0 ± 0.6, 9.7 ± 1.9, P = .009, P = .003, platelet distribution width mean ± SD; 13.0 ± 2.3, 11.4 ± 1.2, 11.7 ± 1.6, P < .001, P = .003, respectively). 

Conclusions: Patients with diabetic neuropathy have subclinical inflammation, and patients with retinopathy have platelet activation. However, further studies are needed to investigate the mechanism of this increased inflammation and platelet reactivity in the development of these complications.

Cite this article as: Şiranlı G, Mertoğlu C, Ersoy A, Karakurt Y, Özçiçek A, Çoban TA. Diyabetik retinopatili hastalarda trombosit aktivitesi artmaktadır. Arch Basic Clin Res 2022;4(2):68-73.

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ISSN 2687-4520 EISSN 2687-4482