Systemic Immune-Inflammation Index as a Biomarker of Psoriasis Severity

Objective: The aim of this study was to investigate the systemic immune-inflammation index as a biomarker of psoriasis skin disease severity and to evaluate its possible relation with psoriasis clinical types.

Methods: Patients with psoriasis and healthy controls were included in this study. Demographic features, disease duration, psoriasis clinical type, and psoriasis area and severity index scores were recorded. Patients were divided into 2 subgroups as mild (psoriasis area and severity index < 10) and moderate/severe psoriasis (psoriasis area and severity index ≥ 10). Systemic immune-inflammation index was calculated by using neutrophil, platelet, and lymphocyte counts in complete blood count (neutrophil platelet/lymphocyte). The differences in systemic immune-inflammation index between groups and correlations between systemic immune-inflammation index and psoriasis area and severity index were analyzed.

Results: Two hundred nineteen cases with psoriasis and 200 controls were included. Systemic immune-inflammation index values were found to be significantly higher in patients with psoriasis than in controls (P = .021). The correlation coefficients between psoriasis area and severity index scores and systemic immune-inflammation index values in all patients, in patients with mild psoriasis, and in patients with moderate/severe psoriasis were P < .01, r = 0.196; P < .05, r = 0.215, and; P < .05, r = 0.217, respectively. There was no statistically significant correlation between systemic immune-inflammation index and types of psoriasis. Also systemic immuneinflammation index >510, 69 was determined as a cutoff point with a sensitivity of 52.5% and specificity of 82.5%.

Conclusion: Systemic immune-inflammation index was found to be significantly higher in patients with psoriasis than in healthy controls with a discriminant ability. Systemic immune-inflammation index may serve as a supportive method in clinical settings.

Cite this article as: Melikoglu M, Pala E. Systemic immune-inflammation index as a biomarker of psoriasis severity. Arch Basic Clin Res. 2023;5(2):291-295.