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Objective: This retrospective study investigated the association between pre-treatment sarcopenia values and inflammatory biomarkers in patients with pancreatic cancer (PC), and assessed the relationship of sarcopenia with postoperative complications, survival, and the duration of hospitalization and intensive care unit (ICU) stay.
Methods: Radiological images, demographic data, and laboratory parameters were perused retrospectively. The skeletal muscle area, considered an indicator of muscle mass, was measured utilizing the OsiriX software system on the computed tomography scans acquired at diagnosis. Thus, the skeletal muscle index was obtained by dividing the skeletal muscle area by the square of the body height (cm2/m2). The inflammatory biomarkers, postoperative complications, and durations of hospitalization and ICU stays were investigated.
Results: A total of 104 patients, including 36 females and 68 males, were classified into 2 main categories: sarcopenic (72 patients) and non-sarcopenic (32 patients). The durations of hospitalization and ICU stay were 14.7 days and 5.6 days, respectively, for sarcopenic individuals and 7 days and 1.6 days, respectively, for non-sarcopenic individuals. Of the 72 patients experiencing postoperative complications, 9 were non-sarcopenic, while 63 were sarcopenic. In terms of the neutrophil-to-lymphocyte ratio and the plateletto-lymphocyte ratio, the patients were compared. Both ratios of the sarcopenic group were significantly higher compared to those of the non-sarcopenic category (P < .001).
Conclusion: In patients undergoing PC treatment, sarcopenia increases postoperative complications and prolongs hospital and ICU stays.
Cite this article as: Gür Özcan SG, Erkan M, Özyıldırım S, Kaçan T. The association of sarcopenia with inflammatory biomarkers, postoperative complications, and hospitalization duration in patients undergoing treatment for pancreatic cancer. Arch Basic Clin Res. 2025;7(1):9-14.