Archives of Basic and Clinical Research
Original Article

Can We Predict Spontaneous Abortion Cases Using the Systemic Immune Inflammation Index?


Department of Obstetrics and Gynecology, University of Health Sciences, Trabzon Kanuni Training and Research Hospital, Trabzon, Türkiye


Department of Obstetrics and Gynecology, University of Health Sciences, Somalia Recep Tayyip Erdoğan Health Practice and Research Hospital, Mogadishu, Somalia

Arch Basic Clin Res 2023; 5: 325-329
DOI: 10.5152/ABCR.2023.23164
Read: 444 Downloads: 289 Published: 10 June 2023

Objective: The aim of this study was to find out if the systemic immune-inflammation index is linked to cases of spontaneous abortion.

Methods: The retrospective analysis included 828 pregnant women who had a spontaneous abortion (study) and 825 women who had a viable intrauterine pregnancy (control) up to 20 weeks. The neutrophil-to-lymphocyte ratio was calculated by dividing neutrophils by lymphocytes. Splitting platelets into lymphocytes calculates the platelet-to-lymphocyte ratio. Systemic immune-inflammation index was determined using the neutrophil × platelet/lymphocyte formula. The study and control groups were compared using an independent t-test. The systemic immune-inflammation index, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio values were evaluated for their ability to predict spontaneous abortion using receiver operating characteristic curves.

Results: The systemic immune-inflammation index values, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio demonstrated a significant difference between the groups. In the logistic regression analyses, we found a positive predictive effect of systemic immune-inflammation index in the prediction of spontaneous abortion. For systemic immune-inflammation index at a cut-off level of 435.26, the sensitivity was 71.2% and the specificity was 67.6. The sensitivity and specificity of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio were found to be lower than systemic immune-inflammation index in spontaneous abortion cases.

Conclusion: Systemic immune-inflammation index may be used as a marker of inflammation in spontaneous abortion cases. It appears to be a more specific marker for indicating inflammation than neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio.

Cite this article as: Baki Erin K, Omar Ali A, Erden Ö, Kulaksız D, Erin R. Can we predict spontaneous abortion cases using the systemic immune inflammation index? Arch Basic Clin Res., 2023;5(3):325-329.

EISSN 2687-4482